Goofy Cache Problem...Just to rattle your brain

Helter Skelter [url=http]touched on this[/url] while addressing my pips problem in the updated Fsubice theme.
I have strange things happening on my site from time to time and I believe it is directly related to cache.
I am running IMv1.4 with all updates in place. I have also double checked all the cache-related folders and files for correct permission settings. Reminded by [url=http]this thread.[/url]
If I disable the cache in ACP-IMPortal-Config everything is ok but I think I may lose a bit of performance.
Signed,
Stumped
I have strange things happening on my site from time to time and I believe it is directly related to cache.
I am running IMv1.4 with all updates in place. I have also double checked all the cache-related folders and files for correct permission settings. Reminded by [url=http]this thread.[/url]
If I disable the cache in ACP-IMPortal-Config everything is ok but I think I may lose a bit of performance.

Signed,
Stumped